Tracking of elevated blood pressure values in adolescent athletes at 1-year follow-up

Article Abstract:

High blood pressure (hypertension) is a common problem among adults in the US and is known to be a risk factor for heart disease and stroke. Hypertension is not often diagnosed until affected individuals reach 30 or 40 years of age, yet borderline hypertension is thought to be present long before then. It is likely that the infrequency of medical care sought by adolescents contributes to the lack of early diagnosis of this condition. However, as many as 25 million teenagers participate in organized sports, for which physical examinations are usually required as a prerequisite. To determine if elevated blood pressures observed during examinations done prior to participation in sports were significant, 467 teenagers were evaluated, most of whom were male. Twenty reported a history of raised blood pressure, but none were receiving drug treatment for this condition. Significantly elevated blood pressure was found in 57 students. Forty-six of the affected adolescents had a family history of hypertension, a much higher frequency than in the healthy subjects. Affected students weighed significantly more, but the condition was not significantly related to race or frequent exercise with weights. One year later, 436 students were available for follow-up. Continued elevated blood pressure was found in 43 of the remaining 54 originally affected subjects, while blood pressure had returned to normal in 11. In addition, 14 more students with previously normal blood pressure also had developed higher blood pressure. The study suggests that screening of adolescent athletes for elevated blood pressure is appropriate, and should facilitate early intervention efforts. (Consumer Summary produced by Reliance Medical Information, Inc.)

Hypertension, Medical examination, Athletes, Hypertension in children

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Late clinical presentation of partial carbamyl phosphate synthetase I deficiency

Article Abstract:

A 16-year-old boy was diagnosed with a partial carbamyl phosphate synthetase I (CPS-I) deficiency. CPS-I deficiency is a metabolic disorder that is usually diagnosed in infants and young children. It affects the handling of the urea produced in the body and can result in high levels of ammonia in the blood. The patient was in a coma upon admission to the hospital. He had been suffering from wheezing and flu-like symptoms approximately two months before being admitted to the hospital. His medical history showed an unusually high number of non-specific illnesses throughout his childhood. His coma reversed after treatment with sodium benzoate and sodium phenylacetate. He was treated with oral sodium phenylbutyrate and oral citrulline after being discharged from the hospital. He gained weight, grew two inches and did not develop any respiratory tract illnesses after returning home. Patients suffering from partial CPS-I may not experience any symptoms until adolescence.

Physiological aspects, Urea, Metabolic diseases, Metabolic disorders in children

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