Transforming growth factor beta as a predictor of liver and lung fibrosis after autologous bone marrow transplantation for advanced breast cancer

Article Abstract:

Patients with increased blood levels of transforming growth factor-beta (TGF-beta) may have a higher risk of developing liver or lung fibrosis after high-dose chemotherapy or autologous (self) bone marrow transplantation. TGF-beta may play an important role in the onset of fibrosis, or the formation of fibrous tissue. A study examined the association between TGF-beta levels and liver and lung fibrosis in 41 women with advanced breast cancer before and after high-dose chemotherapy and autologous bone marrow transplantation and in 10 healthy individuals. Before high-dose chemotherapy or bone marrow transplantation, blood levels of TGF-beta were the same in the patients who did not develop liver or lung fibrosis as in the healthy individuals. Pre-treatment levels of TGF-beta were significantly higher in the patients who developed liver or lung fibrosis than in the healthy individuals or in the patients who did not develop fibrosis.

Complications and side effects, Physiological aspects, Breast cancer, Transforming growth factors, Fibrosis

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The quest for a bone marrow donor - optimal or maximal HLA matching?

Article Abstract:

Two 1998 studies shed light on the conditions necessary to ensure a successful bone marrow transplant. One study found that mismatches between different HLA antigens were associated with cancer relapse, graft-versus-host disease, and other complications of transplantation. The other study found that transplants could still be successful even if the donor and recipient had mismatches. But the bone marrow must have most T cells removed and the patient must undergo intensive chemotherapy.

Analysis

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HLA matching for bone marrow transplantation -- how much is enough?

Article Abstract:

Research has shown that there is much more incompatibility between bone marrow donors and potential recipients than was previously known. However, some of the incompatibility is so minor that it does not increase the risk of graft rejection.

Research

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