Transforming growth factor beta2 in labial salivary glands in Sjogren's syndrome
Article Abstract:
Increased levels of transforming growth factor-beta2 (TGF-B2) in the salivary gland tissue of patients with Sjogren's syndrome (SS) indicates that TGF-B2 plays a role in the formation of fibrous scar tissue in these patients. TGF-B2 is a protein that stimulates tissue growth and wound healing. Researchers analyzed salivary gland tissue samples from 5 patients with primary SS, 5 patients with secondary SS, and 6 healthy volunteers. The levels of TGF-B2 were nearly 1.5 times higher in the patients with SS compared to the healthy volunteers. There was no significant difference in TGF-B2 levels between the patients with primary and secondary SS.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1995
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Neutral endopeptidase (EC 3.4.24.11) in labial salivary glands in healthy controls and in patients with Sjogren's syndrome
Article Abstract:
The enzyme neutral endopeptidase (NEP) appears to be present only in nerve fibers but may prove to influence inflammatory activity in salivary glands of patients with Sjogren's syndrome. Endopeptidases accelerate the break down of proteins including nerve proteins. Researchers examined NEP distribution in salivary gland samples from 12 patients with Sjogren's syndrome and 8 healthy volunteers (control group). There was NEP in the ducts, nerve fibers, blood vessels, and nerve sacs surrounding the salivary glands but not within the gland. NEP activity was similar in the patient and control groups.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1996
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Neuropeptides of the autonomic nervous system in Sjogren's syndrome
Article Abstract:
Autonomic nervous system activation, perhaps in response to stress, may have a role in the mouth dryness of Sjogren's syndrome (SS). SS is an autoimmune disorder that causes dry mouth, dry eyes, and inflammation of salivary and tear glands. Researchers compared neuropeptides in saliva, which indicate nerve cell activity, in 12 SS patients and 10 healthy volunteers. Salivary vasoactive intestinal peptide (VIP) and neuropeptide Y outputs were higher in SS patients, and stress was associated with high VIP concentration. Stress may decrease watery saliva output, raising VIP concentration.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1997
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