Transplacental transmission of natural-killer-cell lymphoma
Article Abstract:
A young woman diagnosed with lymphoma near the end of pregnancy transmitted the cancer to her fetus through the placenta. Lymphoma was diagnosed during emergency cesarean delivery of the infant, and the mother died several weeks later. At four weeks of life, the infant developed an elevated white blood cell count, abdominal distension, and a low platelet count. Lymphoma was diagnosed by bone marrow aspiration and biopsy. The infant died at 59 days of age. Maternal cells pass to the fetus during pregnancy, and the genetic similarity of the maternal leukocytes may have prevented a fetal immune response, allowing the tumor cells to engraft.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
A 24-year-old woman with cervical lymphadenopathy, fever, and leukopenia
Article Abstract:
A 24-year-old Asian woman was admitted to a hospital with a fever and enlarged lymph glands in her neck. She was also anemic and had reduced white blood cell levels. Physicians suspected a local infection, but many tests for infectious organisms were negative. One of the lymph nodes was biopsied and showed evidence of pathologic changes typical of Kikuchi's disease. This disease is a benign, transient disorder whose exact cause is unknown. However, it almost always resolves and that was what happened in this case.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
A 50-year-old man with marked splenomegaly and anemia
Article Abstract:
A 50-year-old man with an enlarged spleen and anemia was diagnosed with Waldenstrom's macroglobulinemia. This is a cancer of blood cells that secrete excessive amounts of the IgM antibody. The excess antibody thickens the blood, which causes most of the symptoms.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Investigation of potential HIV transmission to the patients of an HIV-infected surgeon. Academic Relationships With Industry: A New Model for Biomedical Research
- Abstracts: Management of nonulcer dyspepsia. Irritable bowel syndrome. The irritable bowel syndrome
- Abstracts: Health care discussions and treatment for urinary incontinence in U.S. women. The second stage of labor and stress urinary incontinence
- Abstracts: Omphalocele: clinical outcomes in cases with normal karyotypes. Renal biopsy and pregnancy
- Abstracts: Maternal serum placental alkaline phosphatase level and risk for preterm delivery. Microsatellite analysis reveals a high incidence of maternal cell contamination in 46,XX products of conception consisting of villi or a combination of villi and membranous material