Transplantation of anergic histoincompatible bone marrow allografts

Article Abstract:

Inactivating a specific set of T cells while leaving the rest active may allow patients to receive bone marrow transplants without the need for long-term immunosuppressive drugs. These drugs are normally used to prevent a serious reaction between the donor's cells and the recipient's cells called graft-versus-host disease. However, long-term immunosuppression has many side effects. Researchers exposed immune cells from 12 bone marrow donors and 12 patients waiting for a bone marrow transplant to a chemical that blocks the activation of a specific T cell. Then the donor cells were transplanted. Five patients were cured and did not need immunosuppressive drugs.

Prevention, Bone marrow, Bone marrow transplantation, Immunosuppression, Graft versus host reaction, Graft vs. host disease

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Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells

Article Abstract:

Several studies and researches are conducted to explain the impact of the stabilization of beta-catenin on the survival of the regulatory ([T.sub.reg]) cells. Beta-catenin stabilization is found to highly extend the T cell survival, which further helps majorly in the prevention of several inflammatory diseases.

Science & research, Proteins, Phosphorylation, Protein structure, Catenanes

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p27(super)kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes

Article Abstract:

The p27(super)kip1 kinase inhibitor is the most significant regulator in blocking expanding anergic T cells. Drugs to induce antigen-specific T-cell lack of response should therefore incorporate this kinase.

Genetic regulation, Genetic transcription, Transcription (Genetics)

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