Efficacy and Safety of the Oral Neuraminidase Inhibitor Oseltamivir in Treating Acute Influenza: A Randomized Controlled Trial
Article Abstract:
The drug oseltamivir may be effective in reducing the symptoms of influenza. Researchers randomly assigned 627 people with the flu to take 150 milligrams of oseltamivir per day, 300 milligrams of oseltamivir per day or a placebo. Patients who took oseltamivir had less severe illness, fewer symptoms, and recovered faster than those who took a placebo. The drug also reduced the risk of complications such as bronchitis and sinusitis. Patients who took oseltamivir returned to their regular activities 2 to 3 days sooner than those who took a placebo.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2000
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Use of the Oral Neuraminidase Inhibitor Oseltamivir in Experimental Human Influenza: Randomized Controlled Trials for Prevention and Treatment
Article Abstract:
The drug oseltamivir may be effective in preventing influenza and in reducing symptoms in people who have it. This drug inhibits a viral enzyme called neuraminidase, which is thought to be necessary for the virus to reproduce in humans. Researchers randomly assigned 117 healthy volunteers who were susceptible to influenza to take oseltamivir or a placebo. All were inoculated intranasally with the influenza virus. Only 38% who took the drug got influenza compared to 67% of the placebo group. None of those who took the drug shed any virus whereas half the placebo group did. The drug also reduced symptoms in those who did get influenza.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1999
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Use of the selective oral neuraminidase inhibitor oseltamivir to prevent influenza
Article Abstract:
The drug oseltamivir appears to be effective in preventing influenza. Researchers randomly assigned 1,559 healthy people to take one of two dosages of the drug or a placebo for six weeks during the winter of 1997-1998. Based on a laboratory diagnosis consisting of fever, at least one respiratory symptom and at least one other symptom, only 5% of those who took oseltamivir contracted the flu compared to 11% of those who took a placebo. Side effects of the drug included nausea and vomiting.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1999
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