Vascular endothelial growth (VEGF) induces remodeling and enhances T(sub H)2-mediated sensitization and inflammation in the lung
Article Abstract:
Exaggerated levels of vascular endothelial growth factor (VEGF) are present in persons with asthma, but their role in normal and asthmatic lungs are not defined and hence an experiment was conducted by generating lung-targeted transgenic mice to evaluate its role in T-helper type 2 cell (T(sub H)2)-mediated inflammation. The results reveal that VEGF regulation may be therapeutic in asthma and other T(sub H)2 disorders.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants
Article Abstract:
The role of circulating lymphatic endothelial progenitors in de novo lymphangiogenesis in human renal transplants is examined. A stepwise mechanism of inflammation-associated de novo lymphangiogenesis is observed involving potential lymphatic progenitor cells derived from the circulation, transmigrated through the connective tissue stroma and incorporated into the growing lymphatic vessel.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2006
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Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation
Article Abstract:
Research presented concerns the impact of poly(ADP-ribose) polymerase (PARP) activation on endothelial dysfunction in diabetics. Treatment of diabetic mice with a PARP inhibitor shows promise in maintaining vascular health, despite the continuance of severe hyperglycemia.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
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