Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity
Article Abstract:
A study was conducted, by corneal inflammation using a mouse model of corneal inflammation and lymphangiogenesis, to investigate the relationship between corneal inflammation and lymphangiogenesis, and to determine the functional relevance of VEGFR-3 to corneal immunity. The result suggests that regulating the function of VEGFR-3 is a mechanism for modulating adaptive immunity in the periphery.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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Uridine adenosine tetraphosphate: A novel endothelium-derived vasoconstrictive factor
Article Abstract:
The nucleotide uridine adenosine tetraphosphate (Up4A) isolated from the supernatant of stimulated human endothelium and identified by mass spectrometry, is likely to exert vasoconstriction predominantly through P2X1 receptors and also through P2Y2 and P2Y4 receptors. The Up4A is regarded as a novel potent nonpeptidic endothelium-derived vasoconstrictive factor.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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