Vitamin D3 and calcium to prevent hip fractures in elderly women
Article Abstract:
Vitamin D3 and calcium may reduce the risk of hip fractures and nonvertebral fractures in elderly women. Nonvertebral fractures are those not involving the vertebrae. The risk of these kinds of fractures increases significantly with aging, due largely to a reduction in bone density. Increases in parathyroid hormone and decreases in calcium intake contribute to this loss of bone density. Of 1,765 women, ages 69 to 106 and able to walk, 877 took vitamin D3 and calcium and 888 took placebos. After 18 months, the women taking vitamin D3 and calcium had 43% fewer hip fractures and overall 32% fewer nonvertebral fractures than women who took placebos. Parathyroid hormone levels dropped 44% in the women taking vitamin D3 and calcium. Bone density increased an average of 2.7% in the treatment group and decreased 4.6% in the placebo group.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1992
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Treatment of postmenopausal osteoporosis
Article Abstract:
Osteoporosis is characterized by loss of bone that can lead to bone fragility and fracture. Risk factors include physical inactivity, low calcium intake, lean body, smoking, a personal history of fracture or a family history of fracture. Most drugs used to treat osteoporosis reduce bone loss and include estrogen, calcitonin, etidronate and alendronate. Other treatments increase bone formation and include fluoride, parathyroid hormone. Calcium and vitamin D can also reduce the risk of fractures. Raloxifene may prove to be effective in treating osteoporosis.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1998
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Effect of risedronate on the risk of hip fracture in elderly women
Article Abstract:
The drug risedronate (Actonel) can lower the risk of hip fracture in elderly women with osteoporosis, according to a study of 5,445 elderly women with osteoporosis. The drug was less effective in reducing the risk of hip fracture in 3,886 elderly women who did not have osteoporosis but had at least one other risk factor for hip fracture.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2001
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