Vulvar squamous cell carcinoma and papillomaviruses: two separate entities?
Article Abstract:
Vulvar squamous precancers are abnormal growths within the epithelium (the surface layer of cells) of the vulva, the portion of the female genital tract that lies outside of the vagina. Sexual factors, cigarette smoking, and infection with the human papillomavirus have been shown to influence the development of vulvar squamous precancers. The effects of these influences on the development of invasive cancer of the vulva are less clear. However, vulvar cancer has been associated with prior inflammation of the vulva in older women. The relationship between infection with human papillomavirus and vulvar cancer was assessed in 42 cases of vulvar cancer. The influences of age, smoking, and physical features of the tumor on the development of vulvar cancer were also examined. Cases of vulvar cancer were grouped according to degree of tumor development and by similarities in growth patterns. The genetic material of human papillomavirus was detected in 28 percent of the tumors. Intraepithelial-like neoplasms, or tumors that resembled cells within the epithelium, were associated more often with younger ages (averaging 64 years), a history of cigarette smoking, and human papillomavirus infection. In contrast, squamous carcinoma, a cancer of the flat, scaly squamous cells of the epithelium, tended to occur in older women (average age 73 years) and was not as frequently associated with a history of smoking or infection with human papillomavirus. It is concluded that many vulvar cancers may not be related to infection with human papillomavirus. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1991
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Initial chemotherapy followed by surgical cytoreduction for the treatment of stage III/IV epithelial ovarian cancer
Article Abstract:
The differences in morbidity, progression-free interval, and survival in women with advanced epithelial ovarian cancer with initial chemotherapy versus initial surgery are evaluated. The results have shown that initial chemotherapy is a reasonable alternative to initial surgery for the treatment of selected patients with advanced epithelial ovarian cancer.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2006
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Predictors of suboptimal surgical cytoreduction in women treated with initial cytoreductive surgery for advanced stage epithelial ovarian cancer
Article Abstract:
A study aims to determine if a suboptimal cytoreduction could be predicted preoperatively in women with advanced ovarian cancer. Results reveal that a suboptimal cytoreduction confers no survival advantage to women with advanced ovarian cancer.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2005
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