Zidovudine resistance, syncytium-inducing phenotype, and HIV diseases progression in a case-control study
Article Abstract:
Development of syncytium-inducing (SI) capability by HIV may be associated with progression to AIDS in individuals with HIV infection who are treated with zidovudine. HIV with SI capability can cause an increased level of cell toxicity. Among 34 individuals with HIV infection from whom HIV was cultured in the laboratory, 17 had progressed to AIDS or their CD4 cell numbers were less than 200 per cubic milliliter (mm3) and 17 had not progressed to AIDS or their CD4 cell numbers were more than 200 per mm3 (control group). Resistance to zidovudine was significantly higher in the individuals with disease progression than in those from the control group. HIV with SI capability were cultured from 17 individuals with HIV progression, compared with only one individual from the control group.
Publication Name: Journal of Acquired Immune Deficiency Syndromes
Subject: Health
ISSN: 0894-9255
Year: 1993
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Use of HIV viral load in clinical practice: back to the future
Article Abstract:
HIV RNA levels appear to be a significant factor in monitoring patients with HIV infections and in planning their treatments. Studies have shown HIV RNA levels to be important markers for disease progression particularly in conjunction with CD4+ counts. Long-term treatment goals should include reducing HIV RNA levels to undetectable amounts for prolonged periods of time. These goals should be made in light of the patient's initial HIV RNA levels. Back-up plans should be formulated in the event of treatment failure. HIV RNA levels should be evaluated in light of the patient's consistency in taking medications.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1997
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Changes in plasma HIV RNA levels and CD4+ lymphocyte counts predict both response to antiretroviral therapy and therapeutic failure
Article Abstract:
Patients infected with HIV appear to be at lower risk for developing AIDS if they have sustained reductions in HIV-1 RNA levels and CD4+ counts. HIV-1 RNA levels are one way to measure HIV production. Disease progress, HIV-1 RNA levels, and CD4+ counts were analyzed in 270 HIV-infected patients. The risk for developing AIDS was significantly reduced for each three-fold reduction in HIV-1 RNA levels maintained over a 6-month period. Maintaining a low HIV-1 RNA level was a more significant factor in disease progression than the numeric value of the level.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1997
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