CCR5 chemokine receptor variant in HIV-1 mother-to-child transmission and disease progression in children
Article Abstract:
A genetic mutation which may protect adults against HIV infection might not prevent infection of infants born to HIV-infected mothers. A variant of the CCR5 chemokine receptor gene might prevent HIV from infecting cells. Researchers in France studied the gene in 512 children born to HIV-positive mothers. About 10% of both infected and non-infected children had the mutation. Children with the mutation were less likely to have developed serious HIV-related diseases by age 3. This mutation does not prevent mother-to-child HIV transmission, but it may slow disease progression.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1998
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Morbidity and mortality in European children vertically infected by HIV-1
Article Abstract:
Many children infected with HIV at birth may survive beyond the age of 6. Researchers followed 392 children infected at birth with HIV. About 20% of the children developed severe HIV infection during the first year of life but by six years, this figure had only risen to 36%. Only 26% had died by the age of 6. Two-thirds of those alive at 6 years had minor symptoms and many had relatively high CD4 lymphocyte levels. Those children who received antibiotics to prevent opportunistic infections had a lower rate of bacterial infections than children not receiving antibiotics.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1997
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Infant feeding and risk of mother-to-child transmission of HIV-1 in Sao Paulo State, Brazil
Article Abstract:
Breast feeding appears to be a risk factor for the transmission of HIV between mother and child. In a study of 553 children born in Sao Paulo, Brazil, 16% of those born to HIV-infected mothers tested HIV-positive. Twenty-one percent of those who were breastfed developed HIV infection compared to 13% of those fed infant formula. Longer duration of breast feeding and cracked or bleeding nipples were risk factors for transmission of the virus between mother and child. Many of the women did not know they were infected at the time of delivery.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
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