Association of beta3-adrenoceptor polymorphism with obesity and diabetes: current status
Article Abstract:
The single Trp to Arg substitution in the beta3-adrenoceptor is associated with various symptoms of the metabolic syndrome, including obesity and non-insulin-dependent diabetes mellitus (NIDDM). Studies have confirmed a link between the presence of the variant receptor and a higher tendency to gain weight in Western obese individuals as well as with an earlier onset of NIDDM. The variant is more prevalent in obese individuals among the Pima Indians and possibly among Japanese. A weak association between its presence and several symptoms related to the metabolic syndrome has also been found.
Publication Name: Trends in Pharmacological Sciences
Subject: Pharmaceuticals and cosmetics industries
ISSN: 0165-6147
Year: 1997
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Article Abstract:
Jean Galitzky et al's research that provides evidence for the presence of a fourth beta-adrenoceptor in human adipose tissues offers a debate opening and will boost further research on the topic. Their conclusion was based on the assumption that CGP12177A binds to a putative beta-4 adrenoceptor. However, no data are available to support the hypothesis. They also disregarded the fact that CGP12177A serves as a beta-1-adrenoceptor agonist which may have generated the results observed by Galitzky et al.
Publication Name: Trends in Pharmacological Sciences
Subject: Pharmaceuticals and cosmetics industries
ISSN: 0165-6147
Year: 1998
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The involvement of leptin in humans revealed by mutations in leptin and leptin receptor genes
Article Abstract:
Reports citing the occurrence of mutations in leptin and leptin receptor genes have strengthened findings regarding the role of leptin in humans, especially in the regulation of body weight. Montague et al and Strobel et al reported the occurrence of leptin gene mutations in obese patients with very low or undetectable serum leptin. It was also reported that people with mutations in leptin and leptin-receptor genes are unable to enter the puberty stage.
Publication Name: Trends in Pharmacological Sciences
Subject: Pharmaceuticals and cosmetics industries
ISSN: 0165-6147
Year: 1999
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