Release, metabolism and interconversion of adenine and uridine nucleotides: implications for G protein-coupled P2 receptor agonist selectivity

Article Abstract:

Coding sequences for numerous adenosine nucleotide-activated receptors have recently been identified which lends support to the reputation of ATP and ADP as extracellular signalling molecules. Extracellular uridine nucleotides subserve physiologically important roles given the high selectivity of several of the cloned P2Y receptors for UTP or UDP. The molecular cloning of DNA encoding P2 receptors has led to the delineation of the pharmacological selectivity of P2 receptors of defined amino acid sequence. Individual P2 receptors of known sequence and activity can soon be linked with well-defined physiological responses to extracellular nucleotides.

Nucleotides, Adenylic acid, Adenosine monophosphate

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Protease-activated receptors: PAR4 and counting: how long is the course?

Article Abstract:

Cloning has resulted in the creation of four protease-activated receptor (PAR). All four cloned members of the G protein-coupled receptor family have distinct protease-revealed tethered ligands and can be coupled to both G (sub q) and G (sub i). Also, results of northern blot and PCR analysis show that although they have a wide distribution of mRNA, differences exist with regards to their sites of expression. Such differences explain why PAR4 mRNA is low or absent in kidney and PAR 2 mRNA is absent in the brain and in platelets.

Proteases

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P2 purinoceptor-mediated second messenger responses

Article Abstract:

G-protein coupled P2 purinoceptor second messenger responses have been observed in intracellular Ca2+, protein kinase C, adenylate cyclase and mitogenic pathways. Studies indicate that G protein-coupled stimulation of mitogen-activated protein kinase (MARK) is independent of phospholipasee C (PLC). An interesting theory is that PLC-independent processes may have a role in P2 purinoceptor-activattion of MARK.

G proteins, Second messengers (Biochemistry), Second messengers (Cytochemistry)

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