Sauchinone, a Lignan from Saururus chinensis, suppresses iNOS expression through the inhibition of transactivation activity of ReIA of NF-kB
Article Abstract:
Sauchinone, a known lignan, was isolated from the root of Saururus chinensis as an active principle responsible for inhibiting the production of NO in LPS-stimulated RAW264.7 cells by activity-guided fractionation. An electrophoretic mobility shift assay (EMSA) suggested that sauchinone could inhibit production of NO in LPS-stimulated RAW 264.7 cells through the suppression of NF-kB by inhibiting transactivation activity of ReIA subunit.
Publication Name: Planta Medica
Subject: Pharmaceuticals and cosmetics industries
ISSN: 0032-0943
Year: 2003
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Variable influence of kaempferol and myricetin on in vitro hepatocellular cholesterol biosynthesis
Article Abstract:
Some flavonoids such as kaempferol and myricetin are able to considerably stimulate cholesterol biosynthesis, and these effects are more pronounced in rat hepatocytes rather than in HepG2 cells. The opposing effects on cholesterol biosynthesis are exerted in an indirect manner and seem possible through differential modulation of the complex regulation of HMBCoA reductase.
Publication Name: Planta Medica
Subject: Pharmaceuticals and cosmetics industries
ISSN: 0032-0943
Year: 2003
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Relaxant effects of flavonoids in isolated guinea pig trachea and their structure-activity relationships
Article Abstract:
The structure-activity relationships between flavonoids and their tracheal relaxant action are little known. Some 26 natural and synthetic flavonoids are studied in this respect, and it was determined that glycosylation of the hydroxy group at position C-7 of flavones attenuate the relaxant effects.
Publication Name: Planta Medica
Subject: Pharmaceuticals and cosmetics industries
ISSN: 0032-0943
Year: 2003
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