Limbic seizures increase neuronal production of messenger RNA for nerve growth factor

Article Abstract:

Nerve growth factor (NGF) promotes growth and physiologic mechanisms of certain cells within the brain, spinal cord and peripheral nerves of the body. It was first discovered as a product of specific cells within the mouse salivary gland. The production of NGF, or any other protein in the body, relies on the conversion of a set of instructions that is encoded on a chemical template, or messenger RNA which is produced in the cell nucleus. The detection of specific messenger RNA for NGF has been found within the mammalian brain in areas related to emotion and memory (the limbic system and one of its parts, the hippocampus). The synthesis of NGF in these areas may be related to some form of molecular support for certain (cholinergic) neurons of the brain and disturbance of this system may be related to specific pathologies (for example, Alzheimer's disease). The current report demonstrates that seizure of the limbic system causes a dramatic increase in the concentration of messenger RNA for NGF within one hour of the onset of seizure. This association of NGF with a pathologic physiologic activity suggests a mechanism whereby the level of such factors within an adult brain may be modified.

Measurement, Physiological aspects, Sea horses, Nerve growth factor, Limbic system

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Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth

Article Abstract:

Some cells secrete molecules (growth factor) that act on adjacent cells and cause anatomic and functional changes that are vital in the development of multicellular organisms. Growth factors are essential in the constant production of normal blood cells, cells of the skin and gastrointestinal system (gut). A new growth factor, KGF, which has been purified, operates on specific cells of the skin and lining cells (epithelial cells). A newly developed molecular probe can identify cells which contain genetic information for encoding KGF (the transcript) and it has been widely detected in connective tissue (stromal) cells of epithelial origin. KGF is unique from known human growth factors in that it is a stromal epithelial growth factor. Interactions between epithelial cells and their supporting (stromal) tissue is important in the embryologic development of these tissues, although the exact mode of communication between these classes of tissue in unclear. The biochemical properties of KGF suggest that it may be a major local chemical effector (paracrine effector) of epithelial cell growth.

Keratinocytes

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Trypanosome RNA editing: resolved

Article Abstract:

Researchers have determined how the RNA editing that takes place in trypanosomes and related protozoa occurs, discovering a process that conflicts with the editing model that was most popular in 1994. This research is described, and directions for further research are proposed.

Genetic aspects, Genetic research, Trypanosoma

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