NCI: a lab scientist's view, from the director's office

Article Abstract:

Klausner, who still runs his cell-biology, claims he has changed the NCI's culture to emphasize extramural grants and encourage basic science research. He discusses the proposed development of a national cancer genetics network, the allocation of AIDS-research money and advocacy groups.

Management, Officials and employees, Research institutes, Interview, United States. National Cancer Institute, Klausner, Richard

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The structure of photolyase: using photon energy for DNA repair

Article Abstract:

The crystal structure has been determined for photolyase, the enzyme that controls photoreactivation. The process uses exposure to near-UV light to prevent damage to DNA caused by far-UV light. The photoreactivation mechanism is described and background research is reviewed.

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Appropriate partners make good matches

Article Abstract:

Defective DNA mismatch repair is associated with human cancers such as colorectal cancer, and though it has bacterial homologs, the human process is proving to be much more complicated. Recent research has identified a protein involved in mismatch recognition.

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