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Stretching single protein molecules: titin is a weird spring

Article Abstract:

Three research teams stretched the titin molecule, a giant protein involved in striated muscle contraction, to study the elastic forces generated during stretching and relaxation. The unraveling of immunoglobulin domains revealed a strange mixture of unusual reactions.

Author: Erickson, Harold P.

Publisher: American Association for the Advancement of Science
Publication Name: Science
Subject: Science and technology
ISSN: 0036-8075
Year: 1997

Research, Analysis, Striated muscle, Muscle proteins

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GAP into the breach

Article Abstract:

GTPase-activating proteins stimulate the reaction that inactivates GTPase Ras, part of the signaling pathway controlling cell growth. Research on the crystal structure of the complex between Ras and a fragment of p120GAP provides insights into the function of GAPs.

Author: Sprang, Stephen R.

Publisher: American Association for the Advancement of Science
Publication Name: Science
Subject: Science and technology
ISSN: 0036-8075
Year: 1997

Cover Story, Physiological aspects, Cellular signal transduction, Guanosine triphosphatase

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Subjects list: Proteins, Protein structure

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