Why enzymes are proficient catalysts: Beyond the Pauling paradigm
Article Abstract:
Pauling proposed that enzymes are molecules that are complementary in structure to the activated complexes of the reaction that they catalyze rather than entering into reactions. The covalent hypothesis postulated is supported by available experiment data and has significant implications for the design of drug and artificial catalysts, such as catalytic antibodies and engineered proteins.
Publisher: American Chemical Society
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2005
All Other Basic Organic Chemical Manufacturing, Enzymes, Other Basic Organic Chemical Manufacturing, Enzymes for Food Processing, Catalysis, Structure, Catalytic antibodies
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2005
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Understanding the importance ofprotein structure to nature's routes for divergent solution in TIM barrel enzymes
Article Abstract:
The evolution of new enzymes from existing ones through duplication of genes encoding existing enzymes followed by sequence divergence is discussed.
Publisher: American Chemical Society
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2004
United States, Proteins, Protein structure, Enzyme synthesis
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2004
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Subjects list: Research, Enzymes
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