A PHD finger of NURF couples histone H3 c 4 trimethylation with chromatin remodelling
Article Abstract:
A plant homeodomain (PHD) finger of nucleosome remodeling factor (NURF), an ATP-dependent chromatin-remodeling complex, is shown to mediate a direct preferential association with trimethylation of histone H3 lysine4 (H3K4me3) tails. Results suggest that protein WDR5 and NURF function in a common biological pathway in vivo, and that NURF-mediated ATP-dependent chromatin remodeling is directly coupled to H3K4 trimethylation to maintain Hox gene expression patterns during development.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Structural similarity between TAF and the heterotetrameric core of the histone octamer
Article Abstract:
Two TFIID TATA box-binding protein-associated factors (TAF) are presented in a 2.0A resolution structure. The amin-terminal segment of dTAF42 and dTAF62 from Drosophila use the canonical histone fold. It is concluded that the 2.0A resolution structure of the dTAF42/dTAF62 complex gives the first structural knowledge of RNA polymerase II TAFs. The research work represents the starting point for crystallographic, biochemical and genetic studies of TFIID assembly.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Induction temperature of human heat shock factor is reprogrammed in a Drosophila cell environment
Article Abstract:
Heat shock factor (HSF), which binds DNA, appears to be activated less by changes in temperature than by the reaction to those changes of the cell containing the protein. Human HSF expressed in Drosophila cells showed DNA binding and trimerization at about 10 degrees C less than necessary in human cells, whereas Drosophila HSF showed no change in human cells. Human HSF also acts at a lower temperature when expressed in tobacco protoplasts.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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