A Salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion
Article Abstract:
It has been established that the Salmonella Typhimurium type-III secreted protein SptP modulates the actin cytoskeleton by functioning as a GTPase-activating protein for Rac-1 and Cdc42. This research offers a molecular explanation for the rapid reversibility of cellular responses connected with S. Typhimurium entry into cells. It is suggested that Salmonella delivers SopE and SptP into the host cell either sequentially or in varying amounts to prompt the responses connected with the infectious process.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Conserved residues and the mechanism of protein folding
Article Abstract:
A study of the amino acids involved in protein folding reveals conservation of residues taking part in folding. A method that studies the placement of sequences that fold into the native state in chymotrypsin inhibitor 2 (CI2) indicates that residues forming the nucleus are conserved in 23 natural homologs of CI2. The method can be used to determine the folding state of a protein whose structure is known and has a two-state folding kinetics.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Interpreting the folding kinetics of helical proteins
Article Abstract:
A C-alpha-based three-helix-bundle-like protein model with a realistic thermodynamic phase diagram has been used to calculate several hundred protein folding trajectories. It appears that a protein that is optimized for rapid folding has its rate restricted by the collapse transition. Misfolding and non-obligatory intermediates can slow down overall folding. Elimination of non-obligatory intermediates is therefore vital for rapid folding.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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