Uracil-DNA glycosylase acts by substrate autocatalysis
Article Abstract:
It has been established that the uracil-DNA glycosylase UDG catalyzes base excision by a stepwise dissociative process. The glycosylic bond breaks to produce an oxocarbenium cation/anion intermediate.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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Intrinsic motions along an enzymatic reaction trajectory
Article Abstract:
The various intrinsic motions taking place along an enzymatic reaction trajectory of the enzyme adenylate kinase are discussed. A preferred selection of pathway by larger-scale motions in the enzyme often leads to catalysis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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A hierarchy of timescales in protein dynamics is linked to enzyme catalysis
Article Abstract:
Large-scale, slower lid motions that produce a catalytically competent state are facilitated by pico- to nano-second timescale atomic fluctuations in hinge regions of adenylate kinase.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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