A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
Article Abstract:
The rare haematopoietic dendritic cells live in a number of organs and tissues. They are crucial for immune surveillance and control of specific immunity. Some of the tumour necrosis factor receptors (TNFR) are important to control of immune responses. RANK has been characterized as a new member of the TNFR family, and together with a RANK ligand, is important in the regulation of interactions between T cells and dendritic cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate
Article Abstract:
Phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-Psub2) is a key molecule in phosphoinositide signalling. The enzymes producing it in vitro are in type I and II PtdInsP-5-OH kinases or PIP(5)Ks. These substrate specificities are examined, and type I phosphorylates PtdIns-4-P at the D-5 position of the inositol ring. Type II phosphorylates PtdIns-5-P at the D-4 position.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
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