Ways around rejection
Article Abstract:
A study conducted on transgenic mice demonstrates the ways of survival of mismatched grafts of mouse testes that express the ligand for CD95 and those of the rejection of grafts taken from gld-donors that lack functional CD95 ligand. Mismatched grafts of other tissues are recognized by the host's immune system and are rejected by cytotoxic T cells. The T cells which are stimulated by the presence of foreign tissues, express CD95, a cell-surface molecule which kills the foreign cells. Grafts which express the CD95 ligands may decrease the occurrence of graft rejection.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
CD95 ligand in graft rejection
Article Abstract:
Bellgrau and colleagues misinterpreted the concept of CD95 ligand (CD95 L) in graft rejection. A baby hamster kidney fibroblast cell line expressing transfected human CD95L complementary DNA was transplanted into nude mice. The injection of anti-CD95L reversed the rejection of the ligand transfectant, indicating that CD95L induces the rejection. In vivo experiments indicate that granulocytes are involved in the rejection process. CD95L binds to neutrophils and stimulates their cytotoxic mechanism, causing acute graft rejection.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
Prevention and reversal of renal allograft rejection by antibody against CD45RB
Article Abstract:
Monoclonal antibody MB23G2, raised against CD45RB protein, prevents renal allograft rejection in mice. Mice injected with MB23G2, the monoclonal antibody against CD45RB, have normal renal function after allografts. Treatment with the antibody for 4 days reverses acute rejection, and the mice develop a capacity to survive for their natural lifespan. Tolerance to rejection is related to changes in the tyrosine phosphorylation of T-cell substrates required for signal transduction, as CD45RB is a protein-tyrosine phosphatase.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Single optical photon detection with a superconducting tunnel junction. Demonstration of controlled-NOT quantum gates on a pair of superconducting quantum bits
- Abstracts: A successful prediction? Awakenings in the Arctic. Curb on foreign computers puts damper on US climate modelling
- Abstracts: Making the connection. Giving orchids a helping hand
- Abstracts: Ways of the wild: predator relationships. Houston Zoo struts its stuff. Make way for manatees
- Abstracts: Voltage-dependent anchoring of a nematic liquid crystal on a grating surface. Continuous grey-scale image storage using optically aligned nematic liquid crystals