A neuronal ryanodine receptor mediates light-induced phase delays of the circadian clock
Article Abstract:
Circadian clocks are complicated biochemical systems, integrating temporal information relating to the phases of the solar cycle, and adjusting to synchronize to an organism's internal state to the local environment. Nocturnal light is a dominant feature of this entrainment, and in mammals, information about nocturnal light comes from glutamate released from retinal projections to the circadian clock. Ionotropic glutamate receptors are activated for clock resetting, mediating Ca(super2+) influx. It has been found that intracellular Ca(super2+) store depletion during early night, blocks the effects of glutamate.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Utrophin to the rescue
Article Abstract:
Utrophin rescues the dystrophin-deficient muscle in vivo, and can be used to treat Duchenne muscular dystrophy, a muscle-wasting disease that results in cardiac or respiratory failure. Utrophin can functionally substitute dystrophin at the sarcolemma, as it combines with sarcolemmal glycoproteins to form a complex that is similar to the dystrophin-glycoprotein complex. A reduction in muscle wastage in dystrophin-deficient mice expressing a utrophin transgene is observed. A mechanism that upregulates utrophin may serve as a useful treatment method.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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