A nice ring to the centrosome
Article Abstract:
Scientists seem to have finally found the solutions to the mysteries in cytoskeletal research. Two research papers have provided evidence showing that the gamma-tubulin ring complexes are microtubule nucleators that play a major role in microtubule nucleation. In experiments using unfertilized Xenopus eggs, the research showed that gamma-tubulins are located within the pericentriolar material of isolated chromosomes, but move to the minus ends when the microtubules are assembled.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Centractin is an actin homologue associated with the centrosome
Article Abstract:
A new actin-like vertebrate protein, called centractin, has been isolated. A complementary DNA clone of centractin was produced and found to agree with actin's amino-acid sequence 50% of the time. This agreement rose to 70% when conservative amino-acid changes were incorporated. Centractin appears to be common in tissues and in vertebrate species. Moreover, morphological and biochemical analysis of centractin linked it to the centrosomes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Centrosome polarization delivers secretory granules to the immunological synapse
Article Abstract:
The roles of the actin and tubulin cytoskeletons in helping cytotoxic T lymphocytes (CTLs) for granule delivery to immunological synapse are examined. Results reveal that CTLs do not require actin or plus-end microtubule motors for secretion, but instead the centrosome moves to and contacts the plasma membrane at the central supramolecular activation cluster of the immunological synapse.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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