Food and metabolic signalling defects in a Caenorhabditis elegans serotinin-synthesis mutant
Article Abstract:
An analysis of behavioural and neuroendocrine defects due to lack of serotinin signalling was undertaken. The single tryptophan hydroxylase gene in the C.elegans genome sequence is the key enzyme for serotonin biosynthesis. Animals having a tph-1 deletion mutation do not synthesize serotonin, although are fully viable. The action of C. eelgans serotonergic system in metabolic control is similar to mammalian serotonergic input to metabolism and obesity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
Article Abstract:
The Caenorhabditis elegans heterochronic gene pathway comprises regulatory gene cascades. It is shown that let-7 is a heterochronic switch gene, and loss of let-7 activity leads to reiteration of larval cell fates in the adult stage, while an increase leads to expression of adult fates in the larval stages. It is proposed that the sequential expression of lin-4 and let-7 regulatory RNAs leads to transitions in the number of heterochronic regulatory proteins.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
Article Abstract:
The signalling activity of the phosphatidylinositol-3-OH kinase (PI(3)K) protein encoded by the age-1 gene controls longevity and dauer diapause in Caenorhabditis elegans. AGE-1 PI(3)K is involved in neuroendocrine signalling of the dauer pathway. Its absence leads to dauer characteristics and reduced activity decreases the rate of senescence. Phospahatidylinositol-3,4,5-triphosphate signalling acts negatively on the mutations affecting dauer formation that suppress dauer arrest and longevity age-1 phenotypes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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