A positive feedback mechanism governs the polarity and motion of motile cilia
Article Abstract:
The developmental mechanisms that polarize cilia are analyzed by using the ciliated cells in the developing Xenopus larval skin as a model system. The results have shown that during refinement, fluid flow required for determining cilia polarity, thus revealing a novel mechanism in which tissue patterning coupled with fluid flow act in a positive feedback loop to direct the planar polarity cilia.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Insulin disrupts beta-adrenergic signaling to protein kinase A in adipocytes
Article Abstract:
A study is conducted to show that in adipocytes, chronically high insulin levels inhibit beta-adrenergic receptors from activating protein kinase A (PKA). Chronically high insulin levels may disrupt the close apposition of beta-adrenergic receptors and PKA, identifying a new mechanism for crosstalk between heterologous signal transduction pathways.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Visualizing the mechanical activation of Src
Article Abstract:
A genetically encoded Src reporter that enables the imaging and quantification of spatio-temporal activation of Src in live cells using fluorescent resonance energy transfer (FRET). A rapid distal Src activation along the plasma membrane using the Src reporter is observed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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