A protein conjugation system essential for autophagy
Article Abstract:
The process of autophagy for the bulk degradation of proteins is crucial for survival during starvation and cell differentiation. 14 autophagy-defective (apg) mutants of the Saccharomyces cerevisiae yeast have been isolated and the autophagic process examined at molecular level. A unique covalent-modification system is found to be necessary for autophagy to occur.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
The role of autophagy during the early neonatal starvation period
Article Abstract:
Autophagy, the primary means for the degradation of cytoplasmic constituents within lysosomes is induced by neonates. It is stated that the production of amino acids by autophagic degradation of 'self' proteins, which allows for the maintenance of energy homeostasis, is important for survival during neonatal starvation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Article Abstract:
The loss of autophagy causes neurodegeneration even if disease associated mutant proteins is absent. Continuous clearance of diffuse cytosolic proteins through basal autophagy helps prevent the accumulation of abnormal proteins capable of disrupting neural function which finally leads to neurodegeneration.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Atmospheric CO2 concentration and millennial-scale climate change during the last glacial period. Southern Ocean sea-ice extent, productivity and iron flux over the past eight glacial cycles
- Abstracts: Factors affecting nest survival of greater sage-grouse in Northcentral Montana. Demographics of breeding female mallards in Southern Ontario Canada
- Abstracts: American woodcock fall migration using central region band-recovery and wing-collection survey data. Henslow's sparrow winter-survival estimates and response to prescribed burning
- Abstracts: Caching decisions by grey squirrels: a test of the handling time and perishability hypotheses. The innate basis of food-hoarding decisions in grey squirrels: evidence for behavioural adaptations to the oaks
- Abstracts: Opposing LSD1 complexes function in developmental gene activation and repression programmes. Distribution and three-dimensional structure of AIDS virus envelop spikes