Opposing LSD1 complexes function in developmental gene activation and repression programmes
Article Abstract:
The histone lysine demethylase (LSD1) is required for late cell-lineage determination and differentiation during pituitary organogenesis, where LSD1 acts primarily on target gene activation programmes, and in gene repression programmes. Analysis shows that temporal patterns of expression of specific components of LSD1 complexes modulate gene regulatory programmes in many mammalian organs.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Distribution and three-dimensional structure of AIDS virus envelop spikes
Article Abstract:
A study of the distribution and three-dimensional structure of Envelope glycoprotein (Env) spikes on AIDS retroviruses is presented. The available atomic structures are reconciled with the three-dimensional whole spike density map yielding insights into the orientation of Env spike structural elements and possible structural bases of their functions.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Three-dimensional structure of the myosin V inhibited state by cryoelectron tomography
Article Abstract:
The first three-dimensional structure of the myosin V inactive state is presented. The presented structure shows that motor recycling after cargo delivery might occur through transport on actively treadmilling actin filaments rather than by diffusion.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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