A protein kinase encoded by the t complex responder gene causes non-mendelian inheritance
Article Abstract:
It has been possible to use positional cloning to isolate the t-responder (Tcr). It was established that Tcr belongs to a novel protein kinase gene family, known as Smok, expressed during late spermiogenesis. The identification of Tcr as a member of a protein kinase gene family indicates that Smok and Tcr could be elements of a signal cascade that controls flagellar function. The relationship of Smok/Tcr proteins to MARK2 kinase, which phosphorylates microtubule-associated proteins, may also suggest a function for Smok/Tcr on the axoneme.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor
Article Abstract:
Angiotensin II receptors AT1 and AT2 modulate important functions of the central nervous system, including behaviour. A remarkable rise in blood pressure and an increased sensitivity to the pressor action of angiotensin II are observed when the mouse AT2 gene is disrupted. This suggests that AT2 regulates a depressor effect and inhibits the AT1-mediated pressor action of angiotensin. Disruption of the AT2 gene in mice weakened exploratory behaviour and also caused a decrease in body temperature.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Breathing through skin in a newborn mammal
Article Abstract:
Gas exchange through the skin of the Julia Creek dunnart (Sminthopsis douglasi), a marsupial mouse, is the predominant form of O(sub2) and CO(sub2) transfer in the first days following birth. The gaseous metabolism of the lungs and skin were measured, and the skin's contribution to gas exchange was marked, indicating that pulmonary convection is highly inefficient during the early postnatal stages.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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