APOBEC3G cytidine deaminase inhibits retrotransposition of endogenous retroviruses
Article Abstract:
A different level of antiviral control, mediated by APOBEC3G, a member of the cytidine deaminase family that was previously shown to block HIV replication, is identified. It is seen that APOBEC3G markedly inhibits retrotransposition of intracisternal A-particle (IAP0 and MusD elements, and induces G-to-A hypermutations in their DNA copies.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
Article Abstract:
Ppif null mice are protected from ischaemia and reperfusion-induced cell death in vivo, whereas cyclophilin D-overexpressing mice shoe mitochondrial swelling and spontaneous death. Cyclophilin D and the mitochondrial permeability transition are required for mediating Ca (super 2+)-and oxidative damage-induced cell death.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1
Article Abstract:
Post-entry restrictions of HIV-1 infection are exhibited only among owl monkeys of the new world primates. A search for additional RNAi targets unearthed TRIMCyp, an RNAi-response messenger RNA encoding a TRIM5-CypA fusion protein.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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