Altered immune responses in mice lacking inducible nitric oxide synthase
Article Abstract:
A study using mutant mice without the gene for cytokine-inducible nitric oxide synthase (iNOS) was conducted to characterize the biological role of iNOS. The results showed that mutant mice were fertile, viable and without obvious histopathological abnormalities, but were uniformly susceptible to infection by the protozoan parasite Leishmania major compared to wild-type and heterozygous mice. Infected mice also exhibited stronger Th1 type immune response, reduced nonspecific inflammatory response to carrageenin and resistance to lipopolysaccharide-induced mortality.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Critical role of beta7 integrins in formation of the gut-associated lymphoid tissue
Article Abstract:
Beta7-regulated adhesive associations between lymphocytes and endothelial cells determine the gut-associated lymphoid tissue formation. In mice deficient for the beta7 integrin subfamily of adhesion molecules (alpha4beta7 and alphaEbeta7), the development of lymphocytes remains normal. However, the number of intra-epithelial lymphocytes of the intestine (IELs) decreases in these mice. This occurs because alpha4beta7 regulates prothymocyte migration from bone marrow to thymus, and alphaEbeta7 immobilizes a number of IELs.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase
Article Abstract:
A new study shows the oestrogen receptor (ER) isoform, ERalpha, uses a ligand-dependent process to bind to the p85alpha regulatory subunit of phosphatidylinositol-3-OH kinase.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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