Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of I-kappa-B kinase
Article Abstract:
It has been possible to demonstrate an unusual mechanism of anti-inflammatory activity based on the direct inhibition and modification of the IKK-beta subunit of I-kappa-B kinase. IKK-beta activates NF-kappa-B by pro-inflammatory stimuli, and this research therefore demonstrates how cyclopentenone prostaglandins act and can be used to boost the utility of COX2 inhibitors. This research indicates that cyclopentenone prostaglandin and possibly stronger derivatives could play a valuable role in the treatment of inflammatory and viral diseases, along with some cancers.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
NAK is an IkB kinase-activating kinase
Article Abstract:
An IKB kinase (IKK)-related kinase, NAK that can activate IKK via direct phosphorylation, is described.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
IKK-varGamma is an essential regulatory subunit of the IvarKappaB kinase complex
Article Abstract:
The transcription factor NF-varKappaB is activated by pro-inflammatory cytokines by the stimulation of a protein kinase, phosphorylating IvarKappaB. This leads to the translocation of freed NF-varKappaB dimers and activation of transcription of target genes, many of which code for immunoregulatory proteins. The IKK complex has been purified to homogeneity from human cell lines and it was found to comprise similar amounts of IKK-alpha, IKK-beta and two other polypeptides.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Regulation of chromatin structure by site-specific histone H3 methyltransferases. The language of covalent histone modifications
- Abstracts: Cyclic AMP/GMP-dependent modulation of Ca (super)2+ channels sets the polarity of nerve growth-cone turning. Calcium signalling in the guidance of nerve growth by netrin-1