Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines
Article Abstract:
Research is presented concerning the influence of Cyclin E-Cdk2 levels of activity on the exit from the cell cycle during mammalian embryogenesis and the development of Drosophila. The role of protein degradation is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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A recurrent mutation in PALB2 in Finnish cancer families
Article Abstract:
Researchers have shown, by screening for PALB2 mutations in Finland that a frameshift mutation, is present at elevated frequency in familial breast cancer cases compared with ancestry-matched population controls. The results have indicated that PALB2 is a breast cancer susceptibility gene that might also contribute to familial prostate cancer development.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Isolation of rare circulating tumour cells in cancer patients by microchip technology
Article Abstract:
The construction of a novel microfluidic system (the' CTC-chip') for effective and selective disintegration of feasible circulating tumor cells (CTCs) from peripheral whole blood samples, intervened by the interaction of target CTCs with antibody (EpCAM)-coated microposts under accurately controlled laminar flow conditions is described. The CTC-chip is efficient in precise identification and measurement of CTCs in cancer patients.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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