Autocatalytic processing of the 20S proteasome
Article Abstract:
The autocatalytic propeptide processing in the proteasome of Thermoplasma acidophilum is intermolecular. This processing is unessential for assembly and is independent of propeptide length and sequence. It takes place prior to completion of beta-subunit folding. Serine is an active-site nucleophile for proteolysis and cysteine for processing. Threonine is active in both processes. It is conserved in active proteasome subunits.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Structure of a molecular chaperone from a thermophilic archaebacterium
Article Abstract:
The three dimensional shape of the thermosome protein of the thermophilic archaebacterium Pyrodictium occultum has been analyzed. The shape has two rings with eight stacked subunits in a ring positioned face to face. The central hole is 6.7nm wide and contains a mass which partly blocks the opening to each subunit face and is probably connected to the ring.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Snapshots of nuclear pore complexes in action captured by cryo-electron tomography
Article Abstract:
Cryo-electron tomography is used for studying the structure of nuclear pore complexes in their functional environment, which is in intact nuclei of Dictyostelium discoideum. Single-molecule Monte Carlo simulations of nuclear import are performed in order to interpret the cargo distribution in the light of existing models for nuclear import.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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