BMP-4-responsive regulation of dorsal-ventral patterning by the homeobox protein Mix.1
Article Abstract:
A paired class homeobox protein, Mix.1, mediates the bone morphogenetic protein-4 (BMP-4) signalling pathway to dorsal-ventral patterning in Xenopus embryos. Mix.1 messenger RNA causes extensive blood formation in the embryo and alters dorsal mesoderm into a ventral one. Mix.1 expression is activated by BMP-4. Mix.1 forms heterodimers with the dorsalizing gene, siamois, which encodes a homeodomain protein. This protein is structurally similar to Mix.1. Mix.1 obstructs the duplicated axis activated by ectopic siamois expression.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Arkadia enhances nodal-related signalling to induce mesendoderm
Article Abstract:
Research is presented concerning the regulation of the induction of endoderm, mesoderm and mesendoderm tissue by the transforming growth factor beta family members which are nodal-related.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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Induction of the mammalian node requires Arkadia function in the extraembryonic lineages
Article Abstract:
Research is presented concerning the use of the retroviral ROSA betageo gene-trap vector for the production of recessive lethal gene-trap insertion mutations in the stem cells of embryos.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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- Abstracts: Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Specificities of heparan sulphate proteoglycans in developmental processes
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