Better cells for brain repair
Article Abstract:
Two new approaches for brain cell repair are presented. The first approach was developed during research for an effective way to treat Parkinson's disease. It involves the use of myoblast cells genetically engineered to produce tyrosine hydroxylase. Transplantation of the engineered myoblasts in the striatum of Parkinsonian rats did not induce rejection, and expressed the TH gene at a stable level during the six-month duration of the experiment. A second approach involves the use of oligodendrocyte precursors to remyelinate demyelinated axons. This second approach appears to have more promise than intracerebral transplantation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Prospects for new restorative and neuroprotective treatments in Parkinson's disease
Article Abstract:
It has been established that there is gene linkage in rare families with strong patterns of inheritance of Parkinson's disease-like disease. This discovery, along with the identification of the individual genes involved, has given new information about the involvement of particular genes and molecules, especially alpha-synuclein, in Parkinson's disease. This disease is progressive in nature, with slow neuronal degeneration in the substantia nigra. This means that there are opportunities for therapeutic intervention designed to block or slow down the degenerative process.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Self-repair in the brain
Article Abstract:
Self-repair in the brain is examined.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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