Binding of double-strand breaks in DNA by human Rad52 protein
Article Abstract:
It has been established that human Rad52 proteins bind double-strand DNA breaks, protect them from exonuclease attack and encourage end-to-end interactions. It appears that Rad52 and Ku provide alternative means to process double-strand breaks, a finding consistent with the phenotypes of rad52/Ku mutants. Vertebrate cells defective in Rad52 do not show an extreme recombination/repair-defective phenotype, but the role of homologous recombination in the repair of double-strand breaks must not be underestimated.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Synergistic actions of Rad51 and Rad52 in recombination and DNA repair
Article Abstract:
It has been established that hRad52 stimulates the formation of joint molecules between homologous single- and double-stranded DNA molecules. This finding offers an insight into the function of Rad52 in genetic recombination and double-strand break repair. It appears that hRad51 and hRad52 operate together at the single-stranded DNA-binding step that precedes homologous pairing. There is a functional similarity between Rad51-Rad52 and UvsX-UvsY.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins
Article Abstract:
The identification and characterization of the poly(ADP-ribose)-binding zinc finger motifs in several DNA repair/checkpoint proteins are discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2008
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