Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity
Article Abstract:
The structure of botulinum neurotoxins (BoNTs) is reported in complex with its protein receptor, which binds the domain of botulinum neurotoxin sero type B (BoNT/B) bound to the luminal domain of synaptotagmin II. The findingss provide the basis for the rational development of preventive vaccines or inhibitors against these neurotoxins.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Structural basis of cell surface receptor recognition by botulinum neurotoxin B
Article Abstract:
A 'double receptor' model in which botulinum neurotoxins (BoNTs) recognize nerve terminals via interactions with both gangliosides and protein receptors that mediate their entry is proposed. The crystal structure of full-lengthy BoNT/B in complex with the synaptotagmin II (Syt-II) recognition domain at 2.6 A resolution is reported.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Substrate recognition strategy for botulinum neurotoxin serotype A
Article Abstract:
Clostridal neurotoxins (CNTS) are the causative agents of the neuroparalytic diseases botulism and tetanus. The first structure of a CNT endopeptidase in complex with its target SNARE at a resolution of 2.1 A: botulinum neurotoxin serotype A (BoNT/A) protease bound to human SNAP-25 is reported.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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