Cadherin 23 and protocadtherin 15 interact to form tip-link filaments in sensory hair cells
Article Abstract:
The article demonstrates how two cadherin that are linked to inherited forms of deafness in humans interact to form tip links. Results define the molecular composition of tip links providing a conceptual base for exploring the mechanisms of sensory impairment associated with mutations in cadherin 23 (CDH23) and protocadherin 15 (PCDH15).
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
A common progenitor for haematopoietic and endothelial lineages in the zebrafish gastrula
Article Abstract:
Single-cell-resolution fate maps of the zebrafish late blastula and gastrula were constructed in order to demonstrate that individual cells can give rise to both haematopoietic and endothelial cells. The findings present in vivo evidence supporting the existence of the haemangioblast and reveal distinct features of this cell population.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells
Article Abstract:
In sputnik mutants, stereociliary bundles are splayed to various degrees, with individuals displaying reduced or absent mechanotransduction. It is shown that the defects in sputnik mutants are caused by mutations in cadherin 23.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Light on ancient photoreceptors. Cadherin 23 is a component of the tip link in hair-cell stereocilia. Body plans and simple brains
- Abstracts: Patterning of sodium ions and the control of electrons in sodium cobaltate. Structure of a Na(super +)/H(super +) antiporter and insights into mechanism of action and regulation by pH
- Abstracts: Changes in fisheries discard rates and seabird communities. Where leatherback turtles meet fisheries. The cod that got away
- Abstracts: Spatial patterns in species distributions reveal biodiversity change. Extinction risk from climate change