Co-existence of cationic and chloride components in odorant-induced current ofvertebrate olfactory receptor cells
Article Abstract:
The protracted riddle of why displacement of mucusal cations still does not narrow the amplitude of olfactory receptor cell response was clarified. If cations were the sole current carriers, transduction current would be reduced. However, an inward rush of anionic current preserves transduction effectiveness. Flow of calcium through cation-selective channel switches odorant-induced current to contain a inward chloride component. Presence of cationic and chloride components reduces variations in transduction current.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Crystal-clear chloride channels
Article Abstract:
Researchers have linked Dent's disease, a type of hypercalciuric nephrolithiasis, to a defect in a gene called CLCN5. CLCN5 encodes CLC-5, a putative chloride channel. Dent's disease was originally viewed as a dysfunction in renal calcium transport and not of chloride or fluid volume. Two other types of hypercalciuric nephrolithiasis were found to be associated with mutations in the CLCN5 gene.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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