Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel
Article Abstract:
The structural requirements for functionally coupling two domains by combining acetylcholine (ACh)-binding protein, whose structure is determined using atomic resolution, and the pore domain from the serotonin type-3A (5-Ht(sub 3A)) receptor is determined. It can be concluded that the acetylcholine binding protein (AChBP) is capable of conformational change when ACh binding triggers the opening of the ion pore and shows its utility beyond that of a structural surrogate for the ligand binding domain of the Cys-loop receptor superfamily.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol
Article Abstract:
Eukaryotic cells respond to certain hormones and neurotransmitters with raised enzyme phospholipase C activity and increased concentration of (Ca(super2+))i. This is due to the release of Ca(super2+) from intracellular stores. Ca(super2+) entry is believed to be mediated by Drosophila transient receptor potential (TRP) proteins and certain mammalian homologues. HTRPC6 was found to be a non-selective cation channel activated by diacylglycerol. HTRPC3 and HTRPC6 are members of a new family of second-messenger-operated cation channels.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Phospholipase (Cgamma1) controls surface expression of TRPC3 through an intermolecular PH domain
Article Abstract:
A gestalt algorithm is developed to detect hitherto 'invisible' pleckstrin homology (PH) and PH-like domains and a report is made that the partial Ph domain of phospholipase (Cgamma1) (PLC)(gamma1) interacts with a complementary partial PH-like domain in TRPC3. The findings imply a far greater abundance of PH domains than previously appreciated, and suggest that intermolecular PH- like domains represent a widespread signaling mode.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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