Dichotomous regulators
Article Abstract:
Several transcriptional regulators of protein-coding genes activate in one circumstance and repress in another. Sauer and colleagues have shown how Drosophila protein acts as dual-function regulators. The human thyroid receptor and tumor suppressor p-53 also are other examples of dual-function regulators. These transcriptors work by forming a huge preinitiation complex on the promoter. Some activators stimulate transcription by increasing the assembly of the preinitiation complex.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Recognition of bZIP proteins by the human T-cell leukaemia virus transactivator Tax
Article Abstract:
The human T-cell leukemia virus transactivator Tax interacts with the basic region of bZIP proteins, enhancing their DNA binding ability while stimulating bZIP dimerization. Though no specific leucine zipper is required, Tax alters the DNA site selection by creating an affinity to specific DNA binding sites for the Tax-bZIP complexes. This behavior suggests that transcription factor dimerization control is a common regulatory mode.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Enhancement of TBP binding by activators and general transcription factors
Article Abstract:
Eukaryotic transcriptional activators act by promoting assembly of the preinitiation complex. A DNA-crosslinking/immunoprecipitation assay has been used to examined the first stage in the assembly of the preinitiation complex in living cells. The interaction between the TATA-box-binding protein (TBP) and the TATA box, indicate that TBP binding in vivo is strictly controlled.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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- Abstracts: Do rats ape? Predator learning, experimental psychology and novel predictions for mimicry dynamics. What do Diana monkeys know about the focus of attention of a conspecific?
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- Abstracts: A new model system for studying behavioral traditions in animals. Why behaviour patterns that animals learn socially are locally adaptive