Different phenotypes for mice deficient in either activins or activin receptor type II
Article Abstract:
A null mutation in the Act RcII gene in mice is generated utilizing embryonic stem cell technology to study the function of the ActRcII in mammalian reproduction and development. The mice with ActRcII deficiency exhibited facial and skeletal abnormalities identical to the Pierre-Robin syndrome in humans. But the abnormalities did not affect the growth and development of these mice. This indicates that during ActRcII absence other hormones control the growth and development.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Multiple defects and perinatal death in mice deficient in follistatin
Article Abstract:
The function of follistatin in mammals is investigated by using the loss-of-function mutant mice. The absence of follistatin in mice reveals a retardation in growth and a reduction in the diaphragm and intercostal muscle mass. The shiny taut skin, skeletal defects in the ribs and abnormal tooth development are other observed features. These indicate that follistatin has more influence on the growth and regulation of a mammal than activin.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Alpha-inhibin is a tumour-suppressor gene with gonadal specificity in mice
Article Abstract:
Alpha-inhibin, the gene for one of a group of dimeric growth factors, has been identified as a tumor-suppressor gene. The development of gonadal tumors in mice that were bred to lack the alpha-inhibin gene confirmed the gene's role in preventing the uncontrolled growth of cells during the embryonic phase. The alpha-inhibin-deficient mice were produced using homologous recombination in embryonic stem cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors. Distinct functions of the two isoforms of dopamine D2 receptors
- Abstracts: Reduced antinociception in mice lacking neuronal nicotinic receptor subunits. Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic
- Abstracts: Visual differences. Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases. Lipid modification at the N terminus of photoreceptor G-protein alpha-subunit
- Abstracts: No easy answers for UK science. Pondering on British science policy. UK science budget to grow despite economic woes and cap on salaries
- Abstracts: Scaled-down Cluster mission aims for relaunch in 1999. Cluster relaunch looks to minisatellites