Double-helical RNA in satellite tobacco mosaic virus
Article Abstract:
X-ray crystallographic analysis has determined the form of the satellite tobacco mosaic virus (STMV) at 3.5 angstroms. STMV's amino-acids 37-159 are arrayed as an eight-stranded anti-parallel beta-barrel with a Swiss roll shape resembling what has been observed in the coat proteins of other viruses. Moreover, most of STMV's quaternary interactions are caused by a 60-angstrom-long amino-terminal strand. STMV's double-stranded RNA makes up 44% of the genome, the highest percentage found in any virus so far.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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The three-dimensional structure of an intact monoclonal antibody for canine lymphoma
Article Abstract:
The organization of IgG2a, an antitumor monoclonal antibody that attacks canine lymphoma, has been determined at the 3.5 angstrom level. Canine lymphoma is similar to human non-Hodgkin's lymphoma. The antibody's internal arrangement includes an asymmetric conformation, two separately functioning dyads and a two-fold axis pertaining to the Fc part of the molecule. The intricate and adaptable structuring of this antibody has demonstrated anew the immune system's capacity to respond to tumors.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Ordered duplex RNA controls capsid architecture in an icosahedral animal virus
Article Abstract:
X-ray analysis has mapped out the Flock House virus (FHV) down to 3.0 angstroms. FHV, a spherical virus found in insects, mice and fish, consists of a viral capsid containing 60 triangular units. These units in turn are made up of three polypeptides arrayed as a symmetrical icosahedron. An RNA duplex comprised of 20 nucleotides and a protein subunit that regulates subunit interactions are part of this structure. The RNA and a 44-amino-acid polypeptide may affect FHV's ability to infect.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
User Contributions:
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