Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death
Article Abstract:
The importance of the mitochondrial apoptosis-inducing factor in programmed cell death is researched.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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ICOS is essential for effective T-helper-cell responses
Article Abstract:
A new study seeks to determine the physiological function of inducible co-stimulatory molecule (ICOS) in mice.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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Molecular characterization of mitochondrial apoptosis-inducing factor
Article Abstract:
Mitochondria are important in the control of cell death, or apoptosis.An apoptosis-inducing factor (AIF), able to induce apoptosis of isolated nuclei, has been identified and cloned. The AIF flavoprotein can translocated to the nucleus when apoptosis is induced. Recombinant AIF leads to chromatin condensation and large scale DNA fragmentation. Purified mitochondria are induced to release cytochrome c and caspase-9. The wide-ranging caspase inhibitor Z-VAD.fmk. does not prevent any of those effects.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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