The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation
Article Abstract:
A JmiC-domain-containing protein implicated in X-linked mental retardation and epilepsy, JARIDIC/SMCX, contains H3K4 tri-demethylase activity and functions as a transcription repressor. The loss of SMCX activity has impaired the RE-1 silencing transcription factor (REST)-mediated neuronal gene regulation, thus contributing to SMCX-associated X-linked mental retardation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
Article Abstract:
RNA interference (RNAi) is a universal and evolutionarily conserved phenomenon of post-transcriptional gene silencing by means of sequence-specific mRNA degradation, triggered by small double-stranded RNAs. The long-term effect of sustained high-level short hairpin RNA (shRNA) expression in livers of adult mice is systematically investigated.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
Article Abstract:
RNA interference (RNAi) is a universal and evolutionarily conserved phenomenon of post-transcriptional gene silencing by means of sequence-specific mRNA degradation, triggered by small double-stranded RNAs. The long-term effect of sustained high-level short hairpin RNA (shRNA) expression in livers of adult mice is systematically investigated.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
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