Genes required for GABA function in Caenorhabditis elegans
Article Abstract:
The nematode Caenorhabditis elegans requires five genes for proper gamma-aminobutyric acid (GABA) function. These five are unc-25, unc-30, unc-46 unc-47 and unc-49. Each seems responsible for a number of functions, and some appear to encode familiar chemicals. Unc-30 is required for some neural differentiation; unc-25, unc-47 and unc-47 for presynaptic GABAergic function with the latter two influencing the release of GABA into the synaptic cleft; and unc-49 for postsynaptic function.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
The GABAergic nervous system of Caenorhabditis elegans
Article Abstract:
Gamma-aminobutyric acid (GABA) can excite as well as inhibit postsynaptic membranes. It is the most abundant inhibitory neurotransmitter, and its receptors are the target of many drugs and insecticides. The functions of 25 of the 26 GABAergic neurons in the nematode Caenorhabditis elegans were analyzed as to how they control the body and enteric muscles to produce different behaviors.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor
Article Abstract:
Genetic research demonstrates that the Caenorhabditis elegans gene ced-9 protein is involved in the C. elegans cell-death protease CED-3 pathway. Evidence suggests that CED-9 works via two pathways which both involve CED-3 protease inhibition. Heat-shock treatment experiments demonstrate that CED-3 cleavage sites are vital to CED-9 in its role as cell-death inhibitor.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Confusion about form and function clouds launch of EC's Decade of the Brain. Into the mind of a killer
- Abstracts: Pathogenic bacteria induce aversive olfactory learning in Caenorhabditis elegans. C. elegans odour discrimination requires asymmetric diversity in olfactory neurons
- Abstracts: Prizes fail to quell disquiet over UK policy. Physics bears the brunt of research council's accountability demands
- Abstracts: Verdict in French blood trial shames science. Uproar greets new blood scandal indictment. French appeal court sends Allain to jail
- Abstracts: Interhemispheric synchrony of the last deglaciation inferred from alkenone palaeothermometry. Reconstructing sea surface temperature and salinity using delta18O and alkenone records