Genetic instabilities in human cancers
Article Abstract:
The debate concerning human tumours and whether and how they are genetically unstable has continued for decades. Evidence shows that many cancers could be genetically unstable, but the instability operates at two separate levels. The instability has been observed in a small subset of tumours and base substitutions or deletions or insertions of nucleotides. The instability in most other cancers is seen at the chromosome level.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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A gene for neurofibromatosis 2
Article Abstract:
The gene that causes neurofibromatosis 2 (NF2) has been identified from chromosome 22 using positional cloning techniques. The results of this study has made possible the presymptomatic diagnosis of NF2. However, several questions still remain regarding the biology of this gene and others which have already been cloned and identified. Among these is the mechanism by which gene defects lead to the formation of tumor cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Mutations of mitotic checkpoint genes in human cancers
Article Abstract:
Cancer research has established that chromosomal instability is always present when a missing mitotic checkpoint occurs. A human homologue of the yeast BUB1 gene is sometimes deactivated through genetic mutation in cancer cases. The transfer of mutant hBUB1 alleles is disrupted by microsatellite instability. The effects of hBUB1 expression are shown.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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